New research suggests that α-synuclein comes in multiple strains, one of which seeds aggregation of tau.
In neurodegenerative disease, tau is in the dendrites, and scientists are beginning to flesh out ways to block what it does there.
New research strengthens the idea that microglia do far more than scour the brain for emergencies.
Researchers have co-opted a molecular transport system to shuttle Aβ antibodies across the mouse blood-brain barrier. They predict the shuttle could smuggle a variety of drugs into the brain.
A transcription factor thought to mark stressed-out motor neurons activates genes that help them survive. It maintains muscle mass, but not strength.
New strategies may help find and retain participants for Alzheimer’s trials.
Using carbon-14 to estimate the age of neurons, researchers calculate that the human brain produces around 700 new neurons per day...
Though iron gets a bad rap for accumulating in the brains of older people and individuals with neurodegenerative disease, could an abundance of this metal in the blood bode well?
A report on global disease burden found that the number of deaths in China due to Alzheimer’s disease and other dementias doubled between 1990 and 2010.
Researchers have detected elevated endogenous tau in the cerebrospinal fluid of Aβ mouse models.
A study suggests that genes involved in Aβ production and endocytosis mediate ApoE4’s role in Alzheimer’s disease.
Activating translation regulator eIF2alpha restores plasticity and memory in Alzheimer's models.
Advances in RNA sequencing are shedding light on gene regulation and helping scientists make sense of data from genome-wide association studies.
A mouse study suggests it may be possible to co-opt the liver to boost expression of neurotrophins in the brain.
Conventional wisdom says that excess excitation promotes degeneration of motor neurons in ALS, but a new study suggests excitability could be a good thing.