Neural activity sends amyloid precursor proteins into endosomes where β-secretase drives Alzheimer pathology.
A new study proposes microtubule-chopping enzymes as the missing link in the cascade of pathology leading from Aβ to tau to neuronal death.
Studies support the idea that mitochondrial changes drive aging and AD pathogenesis.
A report on global disease burden found that the number of deaths in China due to Alzheimer’s disease and other dementias doubled between 1990 and 2010.
A study suggests that genes involved in Aβ production and endocytosis mediate ApoE4’s role in Alzheimer’s disease.
New research suggests that α-synuclein comes in multiple strains, one of which seeds aggregation of tau.
Protein strains may underlie different tauopathies, according to researchers presented at this year's AAIC meeting in Boston.
Activating translation regulator eIF2alpha restores plasticity and memory in Alzheimer's models.
Using carbon-14 to estimate the age of neurons, researchers calculate that the human brain produces around 700 new neurons per day...
Though iron gets a bad rap for accumulating in the brains of older people and individuals with neurodegenerative disease, could an abundance of this metal in the blood bode well?
Researchers have long assumed that people with familial Alzheimer’s disease make too much Aβ42 in the brain, but they lacked proof.
By looking for structural DNA variations in Alzheimer’s families, researchers identified 18 new genes that may play a role in AD pathology.
Removing a key component of the innate immune system worsens amyloid deposition but improves memory in mice that model Alzheimer's pathology.
AD but no Amyloidβ? Researchers at AAIC 2013 theorized on the pathology underlying this form of dementia.
Advances in RNA sequencing are shedding light on gene regulation and helping scientists make sense of data from genome-wide association studies.