Preliminary data from Parkinson’s Progression Markers Initiative suggests that cerebrospinal fluid biomarkers distinguish the most rapidly progressing form of Parkinson’s.
Researchers nabbed rare variants in Alzheimer’s genes by sequencing DNA from people with very high or very low levels of cerebrospinal fluid biomarkers.
Fueling (or rekindling) controversy over anti-aging benefits of sirtuins, researchers report that Sirt1 lengthens lifespan in mice.
As heat shock protein and co-chaperone team up to shield tau from degradation, they create toxic oligomers.
Amyloid fibrils seeded by Alzheimer’s brain extracts indicate that Aβ forms specific strains in different individuals.
New research connects extracellular Aβ to intracellular kinases that mediate its toxicity.
A new study supports the idea that non-motor symptoms of Parkinson's disease may aid earlier diagnosis.
New imaging data suggests degeneration of the fornix could help identify seniors on the verge of cognitive decline.
Older people improved memory and attention after playing a challenging video game, supporting the idea that multitasking could have benefits for cognition.
FUS, a protein tied to neurodegeneration, normally mends DNA breaks, according to a paper in Nature Neuroscience.
It's not just for neurodevelopment anymore. Death receptor 6—known for pruning axons—also trims unused connections in adulthood, hinting at a function in Alzheimer's.
Proposed preclinical stages for Alzheimer’s disease predict well who is most likely to progress to Alzheimer’s dementia.
A new RNA interference therapy for amyotrophic lateral sclerosis has some success in mice and monkeys.
In the first study of its kind, researchers found a surprisingly low incidence of Lewy body dementias in a U.S. population.
An inhibitor of a cellular stress response prevents neurodegeneration in mice infected with prion protein, and might have potential in other neurodegenerative diseases.