Mouse studies point to a new pathway that mediates motor neuron disease caused by mutations in superoxide dismutase 1.
Neurons clear misfolded proteins at different speeds. Is this why some brain regions are more vulnerable to neurodegeneration than others?
Knocking down tau expression in adult mice diminishes induced seizures.
A DNA-based Aβ vaccine appears safe and produces a strong immune response in monkeys, suggesting it could work in people.
Struggles to develop therapeutic antibodies for prion disease teach scientists how prion protein may kill neurons.
Mass spectrometry data show how γ-secretase modulators skew APP processing toward Aβ40 rather than Aβ42, without upsetting cleavage of other substrates.
Motor and cortical neurons are particularly vulnerable to FUSopathy. A new paper suggests they fail because they depend strongly on FUS to regulate transcription.
Alzheimer’s and prion disease may be linked through an α-secretase.
Researchers identified a genetic variant in the microglial gene CD33 that protects against Alzheimer’s.
Two studies examine factors that heighten the risk for dementia in type 2 diabetes patients. Both highlight depression as a dangerous comorbidity.
Is transfer of tau from one neuron to the next a normal activity, hijacked by pathogenic protein in the case of tauopathies?
Expansions in ataxin-2 can lead to either ALS or spinocerebellar ataxia—even in the same family, according to a new pedigree from New York.
Functional genomics and mouse analyses blame waning levels of histone-binding protein for memory loss in aging.
A stem cell-derived structure mimics crucial features of human brain development and could aid studies in schizophrenia, autism, maybe neurodegeneration.
In sporadic and familial Parkinson's, faulty parkin may damage dopamine neurons by letting a deadly protein linger.