Gene Therapy Rescues Neurons in Parkinson's Model
A two-gene therapy strategy prevents the death of dopamine neurons and preserves their function, according to a study by Jorg Schulz and colleagues at the University of Tubingen in Germany...
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A two-gene therapy strategy prevents the death of dopamine neurons and preserves their function, according to a study by Jorg Schulz and colleagues at the University of Tubingen in Germany...
A new study published today in Science finds that GDNF genes delivered by a lentiviral vector reversed functional deficits and prevented neurodegeneration in a primate model...
It is not only the abnormal product of amyloid precursor protein—the amyloid-β peptide—that interests researchers of Alzheimer's disease. There is also a line of inquiry that hopes to find clues to the disease in the normal function of amyloid precursor protein...
A number of lines of evidence implicate oxidative damage caused by free radicals—particularly reactive oxygen species—as having some role, perhaps even a major or causative one, in the etiology of neurodegenerative diseases...
The abnormal prion protein, but not the normal prion protein, binds with high affinity to plasminogen, a plasma component that has been linked to neurotoxicity, according to a report in the current Nature...
Macrophage activity is thought to play a key role in Alzheimer's and some other neurodegenerative diseases, such as ALS, as well as in autoimmune disorders. The mechanisms that regulate macrophages could...
Undifferentiated cells from the adult spinal cord can generate neurons when transplanted to the adult hippocampus, reveal Fred Gage and his coworkers at the Salk Institute, California, in the current issue of the Journal of Neuroscience...
Mutations in the genes for α-synuclein and parkin have been linked to early-onset Parkinsonism, but the role of genetics in the far more common late-onset disease has been less clear...
The 40th ASCB meeting began its grand kick-off on Saturday December 9 with an opening symposium by four Nobel Laureates, J. Michael Bishop, Joseph Goldstein, Michael Brown, and Harold Varmus. Bishop summarized his discovery of proto-oncogenes...
A trio of articles will appear in tomorrow's issue of Nature, reporting that Aβ peptide immunization reduces a memory deficit in transgenic mouse models of AD...
A study presented earlier this week at the 2000 International Chemical Congress of Pacific Basin Societies in Honolulu found that by manipulating the structure of amyloid-β, it was possible to reduce the peptide's ability...
In today's issue of Science, researchers at the Whitehead Institute and Corning Inc. describe a new microarray technique that can decipher the function of master switches in a cell by identifying the set of genes they control across the entire genome...
The drug selegiline, thought to be neuroprotective, has been used to treat Parkinson's disease for the past 25 years, but a report a few years ago suggested that the drug could accelerate death in patients taking it...
The cause of Alexander's disease, a very rare, inherited CNS disorder, has been traced to the gene for glial fibrillary acidic protein (GFAP), according to a report published in this month's Nature Genetics...
Glial cells quietly play a much bigger role than ever imagined, according to an article in today's issue of Science. Ben Barres and colleagues at Stanford report that astrocytes exert a powerful influence on communication between neurons...