APP’s Better Half? Soluble Fragment Activates Protective Genes
As amyloid precursor protein (APP) gets sliced and diced, the fragments coming off the β-secretase tend to steal the show...
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Does the Intracellular AβPP Fragment Regulate Calcium?
The similarities between the γ-secretase-mediated processing of AβPP and the Notch receptor suggest that the AβPP intracellular domain (AICD), like its Notch counterpart, could play a role in signal transduction...
Huntingtin Regulates BDNF
The gene mutation that causes Huntington's disease has been known for many years, yet the function of the encoded protein, huntingtin, and the pathogenic mechanism of the mutant protein, have remained frustratingly elusive...
The AD-PD Connection—Model Suggests Nigral Role for Aβ
If the amyloid hypothesis can explain Alzheimer disease (AD), can it also explain why some people with AD...
Resisting Apoptosis
Transcription factors of the nuclear factor-kB/rel (NF-kB) family may be important in cell survival by regulating unidentified, antiapoptotic genes. One such gene that protects cells from apoptosis...
ApoE2 Carriers Have Less Brain Atrophy, AD Pathology in Spinal Fluid
The few people who have an ApoE2 allele enjoy reduced risk of late-onset Alzheimer’s disease...
ApoE and Brain Networks—The Anatomy of a Risk Factor
Clinicians have long puzzled over the heterogeneity of Alzheimer disease symptoms...
Scientists See Hope on Horizon Despite Clinical Disappointments
In the last 10 years, no new Alzheimer’s disease drugs have emerged from clinical trials...
Research Brief: Compensation or Constitution—Metabolism in MCI
Functional neuroimaging studies show elevated activation in the brains of patients with mild cognitive impairment (MCI)...
Book Review: Memory Loss—A Practical Guide for Clinicians
The U.S. is confronting a crisis of Alzheimer’s disease as the current number of five million people with AD is expected to swell threefold by 2050
Neuroligin 1—A New Substrate for γ-Secretase
Add another notch in γ-secretase’s belt...
New Guidelines Proposed for Alzheimer's Disease Postmortem Diagnosis
An international group of researchers* have agreed upon recommendations to revise the criteria for postmortem diagnosis of Alzheimer’s disease (AD)...
ApoE4 Gene May Be Risk Factor in Only a Subset of Cases
A new study reports that the ApoE4 gene, previously reported to be over-represented among patients with late onset Alzheimer's disease, appears to be a risk factor only among patients who developed the disease before age 70...
Ibuprofen Linked to Reduced Alzheimer's Risk
Ibuprofen and related drugs may reduce a person’s risk of getting Alzheimer’s disease by 30 to 60 percent, according to a new study by researchers at Johns Hopkins University and the National Institute on Aging...
Clues from the Colombian Countryside
An enormous extended family living in a rural community in Colombia could provide new insights into environmental and genetic factors contributing to Alzheimer’s disease. All family members who were diagnosed...
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