More Clues in the Case, but γ-Secretase Remains at Large
In the search for the elusive γ-secretase that cleaves β-amyloid precursor protein (APP), much attention has been paid to the protein Notch, which is critical in developmental pathways...
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In the search for the elusive γ-secretase that cleaves β-amyloid precursor protein (APP), much attention has been paid to the protein Notch, which is critical in developmental pathways...
At the American Academy of Neurology meeting in Toronto, Scott Small and colleagues presented data suggesting that fMRI can distinguish early AD-related memory decline from other sources of memory decline...
The armadillo gene—so named because its mutated form in fruit flies produces a phenotype with short spiky hairs, reminiscent of those on the armadillo—codes for a protein that is a homologue of the human β-catenin...
Evidence from several sources suggests that the dorsal hippocampus is critical for the formation and storage of spatial information. In the long term, such information is believed to be transferred to the neocortex for storage...
Hopes have been raised that drugs which inhibit the proinflammatory COX-2 enzyme could be effective in treating rheumatoid arthritis and perhaps also Alzheimer's disease...
The "cholinergic hypothesis" of cognition places emphasis on the role of cholinergic neurons in the basal forebrain and their projections to cortical areas...
Genetic testing for the ApoE allele should not be used to aid diagnosis of the sporadic form of Alzheimer's disease, concludes a Stanford University biomedical ethics committee...
A 1997 study indicated that Alzheimer's patients who carried one or both alleles that code for the E4 form of apolipoprotein had more severe neurodegeneration than did patients who carried only alleles coding for the E3 form of the protein...
Researchers studying the molecular basis of long-term potentiation (LTP) have typically focused on the role of NMDA glutamate receptor, but two papers published in the June 11 issue of Science elucidate the role of the other glutamate receptor, the AMPA receptor...
Neurons taken from the brains of deceased Alzheimer's patients exhibit markers for apoptosis, but little is known about what induces the expression of apoptotic genes...
Various recent studies have reported a link between head trauma and and an increased risk of Alzheimer's disease, but why this might be has been a matter of speculation...
In the August issue of Nature Neuroscience, Bruce Lamb and his associates at Case Western report that they have transferred complete copies of genes for mutant human APP and PS-1 into mice that subsequently...
If the inflammatory cytokine tumor necrosis factor α (TNF-α) is at work in Alzheimer's disease, it may not be relying on its well-described, directly apoptotic mechanism to cause problems...
Douglas Smith and his colleagues at the University of Pennsylvania may have filled a gap in research on long-term, neurodegeneration sequelae of brain injuries...
In the current Nature Cell Biology, Susan Lindquis and Jiang Ma of the Howard Hughes Institute at the University of Chicago report that they were able to produce abnormal prion protein (PrP) conformations from normal PrP...