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The possibility of using stem cells from the brain to grow neural tissues has advanced a key step now that British scientists have coaxed certain nerve cells backwards in their development process to the stem cell stage...
Through a nice piece of protein chemistry work, Yu and colleagues from Peter St. George Hyslop’s laboratory have shown that a novel protein, named nicastrin, associates with preseniln 1 and presenilin 2...
A feat that has eluded researchers for some time—the creation of an animal model of human mitochondrial DNA (mtDNA) diseases—has finally been accomplished. Japanese researchers report that they have created mutant mice with a large-scale mtDNA deletion...
A nasally administered vaccine of amyloid-β (Aβ) can significantly reduce the Aβ burden in the brains of transgenic mouse models of Alzheimer's disease, report Howard Weiner, Dennis Selkoe, and their Harvard colleagues...
Neural stem cells have been heralded as a potential therapy to rebuild injured and diseased brain tissue, but to achieve that vision, researchers must decipher the molecular signals that direct the cells to migrate through the brain...
A two-gene therapy strategy prevents the death of dopamine neurons and preserves their function, according to a study by Jorg Schulz and colleagues at the University of Tubingen in Germany...
A new study published today in Science finds that GDNF genes delivered by a lentiviral vector reversed functional deficits and prevented neurodegeneration in a primate model...
It is not only the abnormal product of amyloid precursor protein—the amyloid-β peptide—that interests researchers of Alzheimer's disease. There is also a line of inquiry that hopes to find clues to the disease in the normal function of amyloid precursor protein...
A number of lines of evidence implicate oxidative damage caused by free radicals—particularly reactive oxygen species—as having some role, perhaps even a major or causative one, in the etiology of neurodegenerative diseases...
The abnormal prion protein, but not the normal prion protein, binds with high affinity to plasminogen, a plasma component that has been linked to neurotoxicity, according to a report in the current Nature...
Macrophage activity is thought to play a key role in Alzheimer's and some other neurodegenerative diseases, such as ALS, as well as in autoimmune disorders. The mechanisms that regulate macrophages could...
Undifferentiated cells from the adult spinal cord can generate neurons when transplanted to the adult hippocampus, reveal Fred Gage and his coworkers at the Salk Institute, California, in the current issue of the Journal of Neuroscience...
Mutations in the genes for α-synuclein and parkin have been linked to early-onset Parkinsonism, but the role of genetics in the far more common late-onset disease has been less clear...
The 40th ASCB meeting began its grand kick-off on Saturday December 9 with an opening symposium by four Nobel Laureates, J. Michael Bishop, Joseph Goldstein, Michael Brown, and Harold Varmus. Bishop summarized his discovery of proto-oncogenes...
A trio of articles will appear in tomorrow's issue of Nature, reporting that Aβ peptide immunization reduces a memory deficit in transgenic mouse models of AD...
