Enabling Technologies for Alzheimer Disease Research: Seventh Bar Harbor Workshop, 2007, Part 3
In Alzheimer’s and related neurodegenerative diseases, misfolded proteins that normally are degraded instead accumulate and form aggregates...
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In Alzheimer’s and related neurodegenerative diseases, misfolded proteins that normally are degraded instead accumulate and form aggregates...
Blocking amyloid fibrillization with small molecules is a widely studied strategy for tackling Alzheimer disease and other amyloidoses...
A multinational team of researchers has uncovered a chromosomal deletion that is associated with mental retardation and seizures...
A new study shows striking images of early amyloid deposits on blood vessels of young APP23 transgenic mice...
Scientists took a step closer to a stem cell treatment for neurodegenerative disease this week...
Aβ oligomers made in test tubes or found in conditioned cell-culture medium can put a damper on synaptic plasticity...
One of the big surprises at this year’s Human Amyloid Imaging meeting was the finding that a significant proportion of healthy controls are PIB-positive...
A new approach to detoxifying the amyloid-β (Aβ) peptide borrows from an unlikely source—the field of cancer drugs...
Is it time to redefine ALS?...
Increasing brain expression of the endogenous opioid peptide may contribute to the cognitive impairment triggered by Aβ production...
Two papers out this week focus on synapses, their contents and function, and how amyloid-β (Aβ) might play into both...
Researchers in Germany and the U.S. debut a new type of light microscopy...
Mice with a defect in a mitochondrial dehydrogenase enzyme show age-related neurodegeneration...
An anti-inflammatory drug has shown therapeutic promise in a mouse model of Alzheimer disease...
Alternative splicing of messenger RNAs can result in the production of protein isoforms with different functions...