Acid Bath Stem Cell Papers Retracted
Researchers retract two papers that claimed a quick dunk in acid turns mature mouse lymphocytes into pluripotent cells.
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Music Clears the Fog of Dementia in ‘Alive Inside’
An award-winning film follows a social worker set on bringing music to people with dementia, and documents their unforgettable moments of awakening.
Can Autophagy Protect ALS Cell Models from Mutant TDP-43?
Antipsychotic medications repurposed to accelerate autophagy might prevent cellular toxicity associated with mutant TDP-43.
Inflammation in Midlife May Presage Cognitive Decline
In a large retrospective study, people with the highest plasma levels of an inflammatory protein experienced the greatest decline in reasoning abilities over the next 10 years.
Pocketful of Posies: Does a Supersized Vesicle Bouquet Promote ALS?
In fruit flies that model ALS, presynaptic vesicles gather in unusually large clumps, amplifying signaling at the neuromuscular junction. Does this promote disease?
Novartis to Partner with Banner Health on ApoE4 Prevention Trial
Novartis Pharmaceuticals Corporation will partner with the Banner Alzheimer's Institute testing experimental preclinical therapies in the upcoming Alzheimer's Prevention Initiative ApoE4 study. The study complements the API ADAD trial.
Neurons and Cancer Cells Share Survival Tactics
The enzyme PARC acts as a survival factor in damaged neurons and cancer cells by targeting a pro-apoptotic protein for destruction.
Alzheimer's Association International Conference 2014
Novartis to Partner with Banner Health on ApoE4 Prevention Trial Crenezumab Disappoints in Phase 2, Researchers Remain Hopeful Alzheimer’s Disease: In the Eye of the Patient? References and Thresholds—Amyloid Imaging Protocols Debated at AAIC Anti-Amyloid
Crenezumab Disappoints in Phase 2, Researchers Remain Hopeful
At AAIC 2014, crenezumab Phase 2 trial results stirred debate.
References and Thresholds—Amyloid Imaging Protocols Debated at AAIC
Could tweaking methodologies improve amyloid diagnosis and tracking?
Anti-Amyloid Therapies Combine Forces to Knock Out Plaques
A mouse study testing the combined effects of a BACE inhibitor and plaque-clearing antibody builds new support for a combination strategy aimed at reducing Aβ buildup in people.
Preimplantation Genetic Diagnosis: A Family Choice
For families with autosomal-dominant neurological conditions, the fear of passing on the disease to their children looms large. Now, people at this highest genetic risk can ensure that they have healthy children by undergoing in vitro fertilization follow
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