AD but no Amyloidβ? Researchers at AAIC 2013 theorized on the pathology underlying this form of dementia.
Protein strains may underlie different tauopathies, according to researchers presented at this year's AAIC meeting in Boston.
A study suggests that genes involved in Aβ production and endocytosis mediate ApoE4’s role in Alzheimer’s disease.
Superficial siderosis, a leakage of blood matter onto the outer surface of the cerebral cortex, may be linked to AD and other dementias.
In neurodegenerative disease, tau is in the dendrites, and scientists are beginning to flesh out ways to block what it does there.
Satori Pharmaceuticals, which had been developing γ-secretase modulators for the treatment of Alzheimer's disease, has closed its doors...
Hunting for rare mutations that cause dementia, researchers have spotted, but not yet snagged, some tantalizing candidates.
A parkinsonism-associated ubiquitin ligase interacts with parkin to promote mitophagy.
Rare variants of AD share some common areas of brain atrophy, but are also unique by way of degeneration in specific functional networks that correspond with clinical symptoms.
Brain connections weaken years before cognition in sporadic and familial Alzheimer’s.
Preliminary data from Parkinson’s Progression Markers Initiative suggests that cerebrospinal fluid biomarkers distinguish the most rapidly progressing form of Parkinson’s.
Before cognition falters, Alzheimer’s disease wreaks havoc on synapses, the brain’s subcellular communication hubs.
Brain imaging distinguishes ALS patients with C9ORF72 expansions from those with other forms of the disease.
Since the discovery of nucleotide repeats in the C9ORF72 gene, the hexanucleotides have presented a puzzle for scientists...
Tiny blood vessels in the mouse brain crisscross the cortex, passing from one neural column to the next, like multiple streets between interconnecting city blocks...