Convened by ARUK to learn from the antibody’s billion-dollar bust, industry and academic leaders declare insufficient CNS target engagement, say peripheral sink did not work, and brainstorm how to move forward.
Branch out, scientists at Alzheimer’s Research UK conference say. Go after tau, glial activation, lipids, in a systematic way. Understand how these pathways connect to the amyloid hypothesis.
The acute state of confusion not only accelerates memory loss on its own, but also worsens decline caused by other pathologies, including Alzheimer’s disease.
Neurons of the humble roundworm pack damaged organelles and protein aggregates into giant vesicles and heave them out into extracellular space. Do our neurons do that, too?
Growing expansions in the C9ORF72 gene may lead to earlier onset of amyotrophic lateral sclerosis and/or frontotemporal dementia symptoms with each passing generation.