Imaging technique borrowed from cancer care shows that leaks are worse in people who are cognitively impaired.
Spinal taps have a bad rap. Are headaches really all that common afterwards, and are there ways to prevent them?
The classic kinase cascade conspires to commit programmed axonal degeneration after injury.
For the first time, scientists report a crystal structure of TSPO, a potential target for PET imaging of neuroinflammation.
Scientists have produced an atomic-level picture of a receptor implicated in both the sporadic and familial forms of Alzheimer’s.
The field of tau PET is growing rapidly as the leading tracer T807/AV1451 is more widely used and new compounds from Japan and Switzerland enter the scene with clinical trials of their own.
Loss of the microRNA leads to glutamate toxicity and neurodegeneration.
Data come tumbling in as more people are getting scans with the first widely used tau PET tracer. Scientists at HAI were pleased by how closely degeneration and symptoms match up in Alzheimer’s.
Early data suggest that the T807/AV1451 signal relates to cerebrospinal biomarkers of Alzheimer’s, intensifies by up to 10 percent a year, and might nail diagnoses beyond typical AD.
Researchers explored how the brain’s immune cells influence disease, and how cells and signals from outside the brain pitch in.
Autoradiography confirms that T807/AV1451 binds tau but not TDP-43. Even so, some say the tracer will benefit from more technical work to ensure it will measure small changes robustly in multicenter settings.
An APP variant reported to stave off Alzheimer’s disease occurs in about one in 6,500 Americans.
A TMEM106B variant widely influences the formation of TDP-43 inclusions, even in people without noticeable signs of neurodegeneration.
Researchers strongly agree that brain banks are indispensable for important discoveries in neurodegenerative disease, but funding shortfalls now threaten to stall the pace of progress.
Worldwide, brain banks are combining their holdings into large databases in an effort to better support neurodegenerative disease research.
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