Researchers at a recent Keystone symposium compared the properties of microglia with those of other macrophages in the body. The cells acquire their unique personalities through both their origins and their present environment.
Did you know? The NACC’s brain tissue comes with extensive clinical and cognitive data, enabling in-depth studies.
Worldwide, brain banks are combining their holdings into large databases in an effort to better support neurodegenerative disease research.
Banked brain tissue enables crucial advances in the understanding and treatment of degenerative disorders. As appreciation of the many different variants of neurodegenerative disease is growing, well-preserved tissue is in more demand than ever. Are the ...
Researchers strongly agree that brain banks are indispensable for important discoveries in neurodegenerative disease, but funding shortfalls now threaten to stall the pace of progress.
A TMEM106B variant widely influences the formation of TDP-43 inclusions, even in people without noticeable signs of neurodegeneration.
Neuroinflammation Field Grapples With Complexity at Keystone Symposia Nature Versus Nurture: What Gives Microglia Their Identity? Microglia in Disease: Innocent Bystanders, or Agents of Destruction? United in Confusion: TREM2 Puzzles Researchers in Taos ...
An APP variant reported to stave off Alzheimer’s disease occurs in about one in 6,500 Americans.
Autoradiography confirms that T807/AV1451 binds tau but not TDP-43. Even so, some say the tracer will benefit from more technical work to ensure it will measure small changes robustly in multicenter settings.
At the HAI conference, scientists reported progress toward differential diagnosis of the bewildering spectrum of frontotemporal dementia and atypical Alzheimer’s variants. In some, hypometabolism overlaps with tau, not amyloid.
Researchers explored how the brain’s immune cells influence disease, and how cells and signals from outside the brain pitch in.
Early data suggest that the T807/AV1451 signal relates to cerebrospinal biomarkers of Alzheimer’s, intensifies by up to 10 percent a year, and might nail diagnoses beyond typical AD.
Data come tumbling in as more people are getting scans with the first widely used tau PET tracer. Scientists at HAI were pleased by how closely degeneration and symptoms match up in Alzheimer’s.
Loss of the microRNA leads to glutamate toxicity and neurodegeneration.
Human Amyloid Imaging Meeting Was Abuzz With Talk of Tau Tau Tracer T807/AV1451 Tracks Neurodegenerative Progression Tau PET Fits With CSF, Grows Over Time, Picks up Frontotemporal Cases What If It’s Not Garden-Variety AD? Telling Variants Apart by Where ...