A compound ensures the ALS-linked protein SOD1 and the respiratory enzyme COX are sated with the essential metal.
Attendees grapple with conflicting binding results
Scientists find evidence for an Aβ etiology distinct from Alzheimer’s after brain trauma.
Researchers failed to confirm a high-profile, previous 10-lipid panel, but remain bullish on the potential of blood-based metabolites as biomarkers.
Preliminary data suggests a long lag between Aβ and tau deposits as the disease develops.
In hopes of incorporating spatial navigation as an outcome measures in trials, a virtual version of the Morris water maze aims to bridge mouse and human therapy studies.
While regulators are trying to figure out what went wrong, independent chemists have dug into the mechanism of what may have been a "dirty" drug.
Scientists found Aβ pathology in the brains of young people who got brain tissue grafts from cadavers. In certain rare circumstances, β-amyloid appears to spread from brain to brain.
A large epidemiological study corroborated previous evidence that rates of both cognitive and behavioral impairment are high in people with amyotrophic lateral sclerosis.
Tau Takes Center Stage at 10th Human Amyloid Imaging Conference Tau Tracers Track First Emergence of Tangles in Familial Alzheimer’s Shaky Specificity of Tau PET Ligands Stokes Debate at HAI At HAI, Researchers Explore Diagnostic Potential of a Tau Tracer ...
Using PET, researchers are trying to match tau spread against structural and functional defects.
TREM2 levels tracked with tau, but varied widely among patients and carriers of different mutations, leaving it unclear whether TREM2 helps or hurts.
Aβ hijacks the neuron’s internal mechanism of synaptic plasticity to tip the balance toward long-term depression. Results suggest a new role for a tumor suppressor protein.
Lou Gehrig’s — a name given for good reason? A study supports a correlation between sports and ALS, but it is far from the final word.
Alzforum spoke with UCSD’s incoming leader for Alzheimer’s research. Where does he want to take the Alzheimer’s Disease Cooperative Study and neurodegeneration research in La Jolla and beyond?