Using a viral vector, researchers created mice that express C9ORF72 hexanucleotide repeats in the brain.
In ALS motor neurons, antisense RNA foci outnumber the sense version, and correlate with a marker of pathology.
Denali Therapeutics gets off the ground with one of the largest Series A rounds ever.
Repeated activation of the perforant pathway over five months doubled the area of amyloid plaques in transgenic mice.
A revised plan of action for AD research has emerged from the Alzheimer’s Disease Research Summit 2015.
Scientists find neurodegenerative proteins squirreled away in the skin cells of patients. Could this present an untapped source of biomarkers?
Aβ42 molecules assume an S-shaped configuration within fibrils. The structure varies markedly from that adopted by Aβ40.
A stem cell model suggests the β-secretase-generated C-terminal fragment of the amyloid precursor protein raises tau protein levels.
A discontinued β-secretase blocker reportedly quieted inflammation and cleared amyloid plaques by way of microglial activation.
Knockout mice lived to old age with mild brain abnormalities but no sign of motor neuron disease.
Davies, Sperling Share 2015 Potamkin Prize New PET Tracer Tracks Preclinical Movement Disorders Neurodegenerative Proteins In the Skin Could be Diagnostic The 67th American Academy of Neurology conference drew more than 12,000 attendees to Washington, D.C ...
Several different striatal markers may help researchers track early deterioration in Huntington's and Parkinson’s diseases.
People with at least 16 years of education are less likely to accumulate markers of neurodegeneration in their brains, says a cross-sectional study.
Researchers identify N-terminally extended Aβ peptides that are toxic to synapses and rise after BACE1 inhibition, though whether they occur in human disease remains unclear.
The approach plays neuroinflammation against neurodegeneration. It may be too risky for people because it would instigate multiple sclerosis, but yields information on the choroid plexus.