Upper motor neurons, implicated in many neurodegenerative diseases, are sensitive to both cell stress and hyperexcitability.
All three PET agents demonstrate roughly equivalent abilities to detect brain amyloid, a new analysis finds.
Hollywood turns its attention to a rare form of dementia, giving a personal look at the impact of the disease.
People with Alzheimer’s overexpress the A2A receptor, which suppresses memory in mice.
Mice with amyloid plaques develop runaway neuroinflammation, whereas mice with tau tangles predominantly lose synapses, a gene-expression study reports.
The addition of a sugar to β-secretase ramps up Aβ production. Could reducing that sweet addition slow progression of Alzheimer's?
Neurons derived from stem cells of people with amyotrophic lateral sclerosis bungle the transmission of electrical signals.
Irritability and depression emerge sooner in AD than in the general population.
Both motor neurons in the brain and neuromuscular junctions in the periphery exhibit defects in young ALS mouse models.
High levels foreshadow cognitive loss, hinting at utility as early diagnostic biomarkers.
Using baseline brain scans, the model projects where atrophy will occur and metabolism will wane.
A protein that repairs synapses after hibernation falters in some models of neurodegenerative diseases.
Cross-sectional biomarker data from the Colombian kindred confirm models of biomarker progression, but suggest an earlier drop in brain metabolism.
Partnership will sequence the entire genomes of 3,000 patients.
Three new therapies enhance the therapeutic effects of levodopa.