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Vaccinating Against Plaques

Findings reported in tomorrow’s issue of Nature raise the tantalizing possibility of using vaccination to prevent or ameliorate Alzheimer’s disease. In the study, by Dale Schenk and colleagues at Elan Pharmaceuticals...

For Lack of a Stop Codon

In tomorrow's issue of Nature, Jorge Ghiso and colleagues at New York University, and coworkers at the National Hospital for Neurology and Neurosurgery in London, report that they have found the gene mutation that produces the amyloid in Familial British Dementia (FBD)...

The AMPA Receptor Steps out of the Shadows

Researchers studying the molecular basis of long-term potentiation (LTP) have typically focused on the role of NMDA glutamate receptor, but two papers published in the June 11 issue of Science elucidate the role of the other glutamate receptor, the AMPA receptor...

Biochemical Mechanisms of Long-Term Memory

Evidence from several sources suggests that the dorsal hippocampus is critical for the formation and storage of spatial information. In the long term, such information is believed to be transferred to the neocortex for storage...

Of Presenilins and Armadillos

The armadillo gene—so named because its mutated form in fruit flies produces a phenotype with short spiky hairs, reminiscent of those on the armadillo—codes for a protein that is a homologue of the human β-catenin...

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