Allosteric γ-secretase modulator binds an extracellular pocket on presenilin, changing the active site.
Aβ aggregates can assume a variety of structures that appear to have unique properties.
Could astrocyte neurotransmission explain memory loss in Alzheimer's disease?
Antipsychotic medications repurposed to accelerate autophagy might prevent cellular toxicity associated with mutant TDP-43.
An award-winning film follows a social worker set on bringing music to people with dementia, and documents their unforgettable moments of awakening.
Researchers retract two papers that claimed a quick dunk in acid turns mature mouse lymphocytes into pluripotent cells.
For families with autosomal-dominant neurological conditions, the fear of passing on the disease to their children looms large. Now, people at this highest genetic risk can ensure that they have healthy children by undergoing in vitro fertilization ...
Families considering PGD to avoid passing on disease genes face obstacles such as high cost and invasive procedures.
Several thousand people have used preimplantation genetic diagnosis to avoid passing on pathogenic mutations to their babies, but many families with a history of Alzheimer’s or related diseases remain unaware of this option.
Some macrophages use their dying breath to emit a distress signal that could spell trouble for their neighbors.
The largest meta-analysis done to date confirms dramatic variability in age at onset of autosomal-dominant Alzheimer's disease overall, but finds mutation type and parental age at onset to be strong predictive modulators.
Engaging in cognitive activities throughout life staves off decline. It also delays Aβ accumulation, two studies report.
A novel mutation frays mitochondrial DNA and impedes ATP synthesis in people with an ALS-FTD-like syndrome.
Head injury increases one’s chances of future dementia by 60 percent, according to a study in veterans.
Scientists report that astrocytes help neurons destroy their unwanted mitochondria.