A new mouse study correlates neurofibrillary tangles with navigation difficulties and impaired firing of “grid cells” in the entorhinal cortex.
The protein Zfp106 adheres to hexanucleotide repeats in RNA encoded by C9ORF72, and also binds ALS-associated proteins. It protects mice and flies from motor neuron disease.
Disabling human tau mRNA in mice prevents—even reverses—tau buildup, suggesting a potential treatment for a multitude of human tauopathies.
A study of samples from people as old as 106 finds that with increasing age, the region-specific patterns of gene expression change in glia, but not neurons.
An NIA-sponsored initiative will generate and characterize numerous models carrying late-onset AD genes, advancing the best for preclinical drug testing.
Three cytokines released by activated immune cells in the brain turn astrocytes into neuron-killing machines.
ApoE isoforms switch on APP expression in human neurons with a potency commensurate with their propensity to increase risk for Alzheimer’s disease, but some researchers question the relevance of this pathway in the human brain.
A photo-reactive version of avagacestat revealed the inhibitor binds close to the endoproteolytic site in γ-secretase.
By fusing disordered protein regions to a plant photoreceptor, scientists study how RNA-binding proteins form liquid droplets within the cytoplasm, and what leads these structures to spawn potentially toxic aggregates.
The finding could help researchers develop safer, more effective immunotherapies, and might apply to other types of protein aggregates as well, scientists said.
Large Aβ aggregates unleash smaller soluble oligomers that mess with synapses and rev up microglia.
Among older adults living in Ontario, Canada, dementia incidence crept up the closer people lived to busy roads.
People with a rapidly progressive form of Alzheimer’s have a more diverse collection of Aβ40 fibril conformations than do people whose disease progresses slowly.
As suggested by computer modelling, deep brain stimulation delivering sporadic pulses packs as much therapeutic punch as a steady rhythm, reducing need for battery replacement surgery.
Alzforum reviews the major newsmakers of the past 12 months.