At the HAI conference, scientists reported progress toward differential diagnosis of the bewildering spectrum of frontotemporal dementia and atypical Alzheimer’s variants. In some, hypometabolism overlaps with tau, not amyloid.
Researchers explored how the brain’s immune cells influence disease, and how cells and signals from outside the brain pitch in.
Early data suggest that the T807/AV1451 signal relates to cerebrospinal biomarkers of Alzheimer’s, intensifies by up to 10 percent a year, and might nail diagnoses beyond typical AD.
Data come tumbling in as more people are getting scans with the first widely used tau PET tracer. Scientists at HAI were pleased by how closely degeneration and symptoms match up in Alzheimer’s.
Loss of the microRNA leads to glutamate toxicity and neurodegeneration.
Human Amyloid Imaging Meeting Was Abuzz With Talk of Tau Tau Tracer T807/AV1451 Tracks Neurodegenerative Progression Tau PET Fits With CSF, Grows Over Time, Picks up Frontotemporal Cases What If It’s Not Garden-Variety AD? Telling Variants Apart by Where ...
The field of tau PET is growing rapidly as the leading tracer T807/AV1451 is more widely used and new compounds from Japan and Switzerland enter the scene with clinical trials of their own.
Scientists have produced an atomic-level picture of a receptor implicated in both the sporadic and familial forms of Alzheimer’s.
For the first time, scientists report a crystal structure of TSPO, a potential target for PET imaging of neuroinflammation.
The classic kinase cascade conspires to commit programmed axonal degeneration after injury.
Spinal taps have a bad rap. Are headaches really all that common afterwards, and are there ways to prevent them?
Imaging technique borrowed from cancer care shows that leaks are worse in people who are cognitively impaired.
Upper motor neurons, implicated in many neurodegenerative diseases, are sensitive to both cell stress and hyperexcitability.
All three PET agents demonstrate roughly equivalent abilities to detect brain amyloid, a new analysis finds.
Hollywood turns its attention to a rare form of dementia, giving a personal look at the impact of the disease.
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