Nrf2 Pumps Up Astrocyte Protection of Motor Neurons in ALS Model
Even in the face of mutated Cu/Zn superoxide dismutase (SOD1), sensitive motor neurons can get by with a little extra help from their antioxidant-pumping astrocyte friends...
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Even in the face of mutated Cu/Zn superoxide dismutase (SOD1), sensitive motor neurons can get by with a little extra help from their antioxidant-pumping astrocyte friends...
Creutzfeldt-Jakob disease (CJD) is a fatal and transmissible neurodegenerative disease caused by a buildup of misfolded prion proteins in the brain...
If an end-stage Alzheimer disease patient with difficulty swallowing ends up with a fatal lung infection, does she die from respiratory failure or AD?...
While some neurodegenerative disease therapies focus on signature proteins, a growing number are addressing more fundamentally what sets neurons up for self-destruction...
In discussions of what goes awry during neurodegeneration, the words genome stability, cell cycle, and DNA repair often come out in the same breath...
In the spinal cord, as in life, too much of a good thing can be detrimental...
Researchers are not shy about putting new therapies through preclinical paces...
Researchers show that cultured human motor neurons are killed by rodent or human astrocytes expressing a mutation that causes ALS...
Widely seen as the molecular trigger for a cascade of changes leading to AD, Aβ lurks within the brains of many cognitively normal seniors, too...
In its textbook version, gene transcription is a one-way street...
Kieth A. Crutcher Interviews Rudy Tanzi
The mSOD1 mouse, harboring a mutated human superoxide dismutase (SOD1) gene, has long held the spotlight as the model of choice for ALS...
Once thought to be a simple go-between, RNA is recently attracting much more attention as an important regulator of gene expression in its own right...
Loaded with promise and disappointment, the roller-coaster tale of Alzheimer disease vaccine development has raised hopes and dampened some...
Gumming up the brain years before a person may notice memory loss or other hints of Alzheimer disease, amyloid-β (Aβ) has fueled much of AD research...
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