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Presenting...β-Secretase

According to a report in tomorrow's Science, researchers have uncovered a strong candidate for β-secretase, the mystery enzyme that cleaves APP and allows Aβ to be formed in subsequent cleavages...

Toxic Protofibrillar Aβ

From today's Journal of Neuroscience comes evidence that intermediate Aβ species could be damaging neurons. Dean Hartley, Dennis Selkoe, and their colleagues report that so-called "protofibrillar" Aβ...

APP Has a Role in Synaptic Development

In today's Journal of Neuroscience, Vivian Budnik, Laura Torroja, and their colleagues provide evidence that under normal circumstances, APP is a critical player in the formation and maintenance of synapses...

How to Misfold a Prion Protein

In the current Nature Cell Biology, Susan Lindquis and Jiang Ma of the Howard Hughes Institute at the University of Chicago report that they were able to produce abnormal prion protein (PrP) conformations from normal PrP...

Vaccinating Against Plaques

Findings reported in tomorrow’s issue of Nature raise the tantalizing possibility of using vaccination to prevent or ameliorate Alzheimer’s disease. In the study, by Dale Schenk and colleagues at Elan Pharmaceuticals...

For Lack of a Stop Codon

In tomorrow's issue of Nature, Jorge Ghiso and colleagues at New York University, and coworkers at the National Hospital for Neurology and Neurosurgery in London, report that they have found the gene mutation that produces the amyloid in Familial British Dementia (FBD)...

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