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Soluble Aβ: Getting a Grip on Its Fate

In Alzheimer’s patients, a portion of soluble amyloid-β peptides (sAβ) never makes it out of the brain as in normal subjects, ending up instead in amyloid fibrils or plaques. A trio of recent papers explores factors that determine the fate of these peptides...

ALS—Is It the Neurons or the Glia?

One well-characterized cause of amyotrophic lateral sclerosis (ALS) is mutation of the copper-zinc isoform of superoxide dismutase (SOD), causing progressive degeneration of motor neurons. But must these mutations occur in neurons to be detrimental? A report in today’s Science suggests...

Gleevec for Alzheimer's?

Gleevec, the cancer "wonder drug" that has proven effective for gastrointestinal stromal tumors might also be useful for Alzheimer's patients, if only one could deliver it to the brain effectively...

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