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ApoE(ε)4 Brains Have to Work Harder

The ε4 variant of the apolipoprotein-E (ApoE) gene has been shown to confer increased risk for Alzheimer's disease. Gary Small, Susan Bookheimer, and colleagues report that carriers of the ε4 allele need to exert their brains more...

NFTs in Mice

Mice carrying the P301 mutation in tau, which causes human frontotemporal dementia, develop neurofibrillary pathology with features mimicking those of human tauopathies...

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