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Huntingtin Regulates BDNF

The gene mutation that causes Huntington's disease has been known for many years, yet the function of the encoded protein, huntingtin, and the pathogenic mechanism of the mutant protein, have remained frustratingly elusive...

New Prion Detection Method

Abnormal forms of the prion protein are thought to be the infective agent responsible for bovine spongiform encephalopathy (BSE, or "mad cow disease") and its human form, variant Creutzfeldt-Jakob disease (vCJD)...

New Gene Suspect for ALS

Amyotrophic lateral sclerosis (ALS; also known as Lou Gehrig's disease) is the most common motor neuron disease in humans, affecting one in 1,000. It results in a progressive loss of motor neuron function, leading to...

Neprilysin Role in Amyloid Clearance

While much Alzheimer's research has focused on mechanisms that result in the formation of amyloid plaques, a growing body of evidence indicates that processes that break down Aβ are just as important...

Molecules for Remote Memories

Permanent memories are thought to be stored in the cortex, but little is known about the processes that incorporate memories into cortical . Now Alcino J. Silva and colleagues, have discovered a molecular manipulation that affects memory...

Ultimate Stem Cell in Adult Bone Marrow?

Stem cells from the bone marrow of adults may be as flexible as embryonic stem cells, according a study in the current issue of Cell. Researchers at Yale, New York University, and Johns Hopkins found that these cells...

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