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Progress in Neural Stem Cell Research

Neural stem cells have been heralded as a potential therapy to rebuild injured and diseased brain tissue, but to achieve that vision, researchers must decipher the molecular signals that direct the cells to migrate through the brain...

β-Secretase 3D Structure

Researchers announced a step forward in the rational design of drugs to inhibit β-secretase with the publication in tomorrow's Science of the crystal structure of the enzyme locked in a complex with a novel inhibitor...

A Sniffable Vaccine?

A nasally administered vaccine of amyloid-β (Aβ) can significantly reduce the Aβ burden in the brains of transgenic mouse models of Alzheimer's disease, report Howard Weiner, Dennis Selkoe, and their Harvard colleagues...

Finally, a Mitochondrial Mutant

A feat that has eluded researchers for some time—the creation of an animal model of human mitochondrial DNA (mtDNA) diseases—has finally been accomplished. Japanese researchers report that they have created mutant mice with a large-scale mtDNA deletion...

Another Role for the Prion: Evolutionary Key?

The prion protein, so interesting to researchers of neurodegenerative disease for its novel capacity to cause disease through a change of conformation—and to transmit disease to other cells and organisms through its altered conformation—may have...

News Commentary on Nicastrin

Through a nice piece of protein chemistry work, Yu and colleagues from Peter St. George Hyslop’s laboratory have shown that a novel protein, named nicastrin, associates with preseniln 1 and presenilin 2...

Going Beyond the DNA

High-throughput screening for proteins is now possible, according to report in this month's Nature Biotechnology. Researchers in England have designed an array, similar to DNA microarrays, that can screen for more than 18,000 proteins at once...

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