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Aging with the Right Memory Molecules

This week's issue of Nature features two articles that point to ways in which the targeting of molecules associated with maintenance of cognitive function might one day help boost these functions in both normal and demented older adults.

Caloric Restriction Increases Metabolic Rate

It has been known for sometime that reduced intake of calories increases the lifespan of many species, including mammals, but just exactly how this works is unclear. Now work from Leonard Guarente’s lab at MIT suggests that <em>increased</em> respiration is what extends lifespan—at least in yeast....

New Role for NO in Neuronal Apoptosis

In today’s Science, researchers from the Burnham Institute, La Jolla, California, report a new pathway that can cause neuronal apoptosis, or programmed cell death—the covalent modification of extracellular matrix metalloproteinases (MMPs)....

Fat and Calories Mean Higher AD Risk

When it comes to food and the quality of life there is a growing wealth of knowledge that suggests “less is more.” This mantra is supported by a new study associating high caloric intake with increased risk for Alzheimer’s disease (AD)....

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