The protein FUS forms liquid organelles in healthy cells. Does it trigger neurodegeneration by switching to a solid state?
Appoptosin, a gene linked to progressive supranuclear palsy, triggers tauopathy by activating caspase-3, which cleaves tau to unleash its synaptotoxic potential.
For every unit increase in body mass index in midlife, the age at onset of AD dropped by more than half a year. Amyloid PET links the effect to AD pathology.
At AAIC, researchers reported that estrogen may decrease dementia risk if given to healthy women during early menopause.
Relieving systemic immune suppression facilitates the entry of immune cells into the brain and slows amyloid accumulation in a mouse model of aggressive Aβ pathology, scientists claim.
Scientists flesh out how PINK1 and parkin instigate mitophagy and what role the ALS genes optineuron and TBK1 play in the process.
A third trial continues in the United States
The fragment occurs naturally and rises after BACE inhibition, adding another layer of complexity to inhibitor therapy.
In two trials, moderate exercise or supplements of omega-3 fatty acids and antioxidants failed to alter the course of cognitive decline in older adults.
Three studies report that the C9ORF72 expansion prevents RNAs and proteins from shuttling properly between nucleus and cytosol.
A new report paints a stark picture of the coming wave of dementia cases and their staggering cost if prevention or treatment fails to stem the tide.
Scanning for amyloid plaques in the brain may help clinicians diagnose and manage patients with a questionable diagnosis of Alzheimer’s.
The largest trial yet of ApoE4 carriers is pioneering new protocols with increasing use of technology to reach thousands of potential participants and disclose risk information.
Prevention trials are testing new protocols for telling potential participants about their heightened risk for dementia, and exploring the psychological effect of such disclosures.
The intracellular domain of the amyloid precursor protein may alter gene expression to reduce production of Aβ.