Granules in the nucleus and cytoplasm may owe their genesis and shape to liquefied forms of ALS-linked proteins, such as FUS and hnRNPA1.
Researchers report the first known enzyme that combines disaggregase and protease activity.
A CD33 variant associated with Alzheimer’s boosts levels of wild-type TREM2, hinting that these risk factors could share a common mechanism.
The genetic relics of ancient, dormant retroviruses pepper the human genome. One such virus reanimates in about one-third of ALS cases.
Analysis of the avagacestat trial of 2012 details the side effects that sank the drug, and the outcomes that support CSF biomarkers for prodromal Alzheimer’s disease.
The 1000 Genomes consortium released its final report and sequence data set. It will help scientists studying neurodegenerative diseases better interpret GWAS findings.
Acetylated tau accumulates in Alzheimer’s disease, and associates with pathology and behavioral measures in mouse models.
Drosophila were just fine, thank you very much, despite carrying the ALS- and FTD-linked repeats in the same intronic context as they occur in people.
In a large population study, middle-aged people who developed atrial fibrillation were about twice as likely as their peers to succumb to dementia over the next 20 years.
GATA4 transcription factor connects selective autophagy to pro-inflammatory state of cells harboring DNA damage. Researchers propose the pathway may play a role in age-related disease.
Avanir Pharmaceuticals’ AVP-923 calmed Alzheimer’s patients in a small 10-week study.
Mutations in CHMP2B gene have been linked to mysterious lysosomal inclusions.
Mouse studies show the peptide damages the borders between the circulation and central nervous system, but also find that a weakened wall helps clear Aβ from the brain.
Levels of CSF biomarker neurogranin correlate with imaging measures of synaptic integrity in ADNI cohort.
Extracted from the brains of people who had this particular synucleinopathy, but not, it appears, from those with Parkinson’s, α-synuclein spreads like a prion when injected into mice.