Exercising the brain and body in middle age may not limit progression of Alzheimer’s pathology.
Proteolysis of other substrates, including Neuregulin, proceeds apace.
An Italian study links the supposedly protective ApoE2 gene to frontotemporal dementia in amyotrophic lateral sclerosis.
Researchers report the first successful use of this technology to detect soluble Aβ in the brains of Alzheimer’s mouse models.
Genetic deletion of white blood cells in an Alzheimer’s mouse model quadrupled plaque load, but restoring peripheral antibodies halved this increase.
Overly active interneurons fire up pyramidal neurons in mice with mutant TDP-43.
A new procedure turns circulating immune cells into neurons. It could simplify how scientists make patient-specific disease models.
Caging an HDAC inhibitor in a lipid chelator raised plasma and brain concentrations of the drug and doubled the lifespan of a mouse model of Niemann-Pick type C disease.
Some repeats seem to interfere with regulation of translation, causing dendrites to shrink.
Older people who regularly used proton pump inhibitors had a greater risk of mental decline.
A free, open online course on rare forms of Alzheimer’s, Lewy body, and frontotemporal dementia aims to spread knowledge while harnessing social learning.
Newly discovered Aβ effects of this cancer drug may be unrelated to its previously known mechanism of action.
Data from the Framingham Heart Study support the idea that dementia incidence is on the decline, but researchers are still dissecting the factors responsible.
Only mutant transgenes, not wild-type, cause disease.
The jury is out on whether the drug shifts Aβ in people.