The 1000 Genomes consortium released its final report and sequence data set. It will help scientists studying neurodegenerative diseases better interpret GWAS findings.
Acetylated tau accumulates in Alzheimer’s disease, and associates with pathology and behavioral measures in mouse models.
Drosophila were just fine, thank you very much, despite carrying the ALS- and FTD-linked repeats in the same intronic context as they occur in people.
In a large population study, middle-aged people who developed atrial fibrillation were about twice as likely as their peers to succumb to dementia over the next 20 years.
GATA4 transcription factor connects selective autophagy to pro-inflammatory state of cells harboring DNA damage. Researchers propose the pathway may play a role in age-related disease.
Avanir Pharmaceuticals’ AVP-923 calmed Alzheimer’s patients in a small 10-week study.
Mutations in CHMP2B gene have been linked to mysterious lysosomal inclusions.
Mouse studies show the peptide damages the borders between the circulation and central nervous system, but also find that a weakened wall helps clear Aβ from the brain.
Levels of CSF biomarker neurogranin correlate with imaging measures of synaptic integrity in ADNI cohort.
Extracted from the brains of people who had this particular synucleinopathy, but not, it appears, from those with Parkinson’s, α-synuclein spreads like a prion when injected into mice.
The latest optical-clearing technique exposes three-dimensional interactions between plaques, microglia, and blood vessels. It even zooms in on synapses.
Micro-electron diffraction reveals atomic resolution of β-sheet structure in an α-synuclein crystal, while a close-up of Aβ fibrils surprises with turns shaped like a tilde.
Gastrointestinal adverse events prompted the FDA to press the pause button on the α7 nicotinic acetylcholine receptor agonist.
Researchers using transcranial magnetic stimulation report that C9ORF72-based ALS, like other forms, leads to motor cortex hyperexcitability.
Paper Alert: Longitudinal Data Support CSF Neurogranin as an Early Synaptic Marker of Alzheimer’s Disease
Neurogranin could be a promising early CSF biomarker of Alzheimer’s disease.