Two international initiatives compile metadata from aging and AD studies into huge searchable catalogs in hopes of speeding research progress.
Before any other changes, the fatty coating on peripheral nerve fibers breaks apart, heralding their degeneration.
Trial sponsors moved children from ongoing trials to open-label studies following positive interim results of an antisense oligonucleotide treatment.
A synthetic amyloid harmed cultured cells only when it deprived them of an essential protein.
Mice expressing a mutant version of human UBQLN2 develop TDP-43 pathology in their spinal cords, while losing motor neurons, muscle mass, and muscle innervation of with age.
As reported at meetings, Merck’s BACE inhibitor reduced CSF Aβ in animals and people with apparently few side effects. Researchers express optimism for the drug and others in its class.
In Italian memory clinics, the PET scans resulted in diagnosis and medication changes for up to a third of patients.
In development, the brain follows a set of rules when it folds to form its ridges and grooves. Those rules change with age, and especially in Alzheimer’s.
Despite no warning signs in ongoing clinical trials, researchers are searching for safer drugs, and better biomarkers to measure what they do.
In Seeon, researchers reported that blocking the protease may heal dystrophic neurites and repair electrical activity.
Human neurons expressing presenilin and APP mutations shuttled less cholesterol to axons; inhibiting β-secretase restored normal transport, hinting that APP C-terminal fragments may be involved.
At the 2nd Kloster Seeon meeting on BACE proteases, researchers linked BACE substrates to regulation of synaptic activity.
When the brain is starved of BIN1, endocytosis goes into overdrive. Vesicles gulp more tau aggregates into neurons, feeding their spread.
Two labs report that dipeptide repeats derived from C9ORF72 latch onto TDP43, FUS, and other proteins that form liquid organelles. The liquid then gels, retarding cellular functions.
Researchers at the Kloster Seeon meeting pressed in on the question of what are the physiological functions of this protease after development is complete.
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