Building a Roadmap for Shared Combination Drug Trials
As potential AD drugs continue to post disappointing Phase 2/3 results, many in the field are considering upping the artillery by testing experimental drugs in combination.
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DSM-5: Debated? Yes. Important for AD Diagnosis? Maybe Not
After more than a decade in the works, the long-awaited fifth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) arrived last month to little fanfare.
Genotype-Based Meta-Analysis Suggests Serum Iron Protects Against PD
Though iron gets a bad rap for accumulating in the brains of older people and individuals with neurodegenerative disease, could an abundance of this metal in the blood bode well?
Mouse Brain Circulatory System Knows No Bounds
Tiny blood vessels in the mouse brain crisscross the cortex, passing from one neural column to the next, like multiple streets between interconnecting city blocks...
Satori Pharmaceuticals Shuts Down, Abandons γ-Secretase Modulators
Satori Pharmaceuticals, which had been developing γ-secretase modulators for the treatment of Alzheimer's disease, has closed its doors...
Brain Changes Speak Volumes About Normal Aging and Dementia
Brain atrophy plagues more than just people with neurodegenerative disorders...
Newborn Neurons Abundant in Adult Human Hippocampus
Using carbon-14 to estimate the age of neurons, researchers calculate that the human brain produces around 700 new neurons per day...
Methylation a Turn Off for Disease Gene C9ORF72?
Since the discovery of nucleotide repeats in the C9ORF72 gene, the hexanucleotides have presented a puzzle for scientists...
Single-Blind Trial: Diabetes Drug Helps Parkinson’s, Maybe
Could an approved diabetes medication treat Parkinson’s disease?...
G8 to Set Sights on Dementia
This June, leaders from the globe’s eight richest countries, the G8, will assemble to discuss major economic issues—among them, the rising threat of dementia in aging populations...
Does Shrinking Temporal Lobe Make AD Patients Overly Sensitive?
Though typically seen as a cognitive disorder, Alzheimer’s disease can throw emotions off kilter, making people unusually sensitive to others’ feelings and moods...
The Power of Three: Genetic Trios Yield ALS Gene Candidates
The May 26 Nature Neuroscience online debuts 25 new candidate genes for amyotrophic lateral sclerosis...
Alzheimer’s Disease Snags High-Profile Prize
The focus of the next XPRIZE is Alzheimer’s disease...
Limited Protein Shapes May Explain Drug Side Effects
A new study explains why many drugs come with similar side effects...
A Protein-Based Study of Parkinsonism’s Incidence
In a study, scientists included rare types of parkinsonism and categorized them by their underlying proteinopathy...
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