New Theory for Some ALS Cases—SOD1 Plugs Cell Power Plants
The misfolded enzyme that causes some kinds of amyotrophic lateral sclerosis poisons motor neurons by plugging up pores in their mitochondria...
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The misfolded enzyme that causes some kinds of amyotrophic lateral sclerosis poisons motor neurons by plugging up pores in their mitochondria...
Several studies have shown that Alzheimer’s patients appear to be less susceptible to cancer, but the mechanism behind this association remains mysterious...
Getting hit in the head might not just ring your bell—in rare cases, it may predispose athletes in contact sports to motor neuron disease...
Surprisingly little is known about how AD affects the electrical activity of the hippocampus...
Mounting evidence suggests that immune system molecules can wear different hats in the central nervous system...
There is a new ingredient in the complex mix that yields masses of malformed proteins...
Inhibition of the β-secretase enzyme has long been seen as one of the most promising therapeutic options for Alzheimer disease...
Eli Lilly and Company announced yesterday that it has halted its Semagacestat γ-secretase inhibitor program...
There is a new TDP-43 mouse in town...
A γ-secretase inhibitor that doesn’t block γ-secretase may seem like a bit of an oxymoron, but there are some compounds that appear to do just that...
A new study suggests that age-related protein aggregation might be widespread even in healthy organisms...
In clinical research, a first-time finding may rouse intrigue, but it’s generally independent confirmations of the data that give them potential to leave an indelible mark...
Honolulu: FDA Approval in Sight for 18F Amyloid Tracer Florbetapir? Honolulu: Tomm40 Reported to Track With Brain Atrophy, Cognition Honolulu: TrialMatch Launched as AD Is Becoming “Desktop” Disease Honolulu: The Missing Link? Tau Mediates Aβ Toxicity at
Top-line data announced this week from a Phase 2 clinical trial of the drug scyllo-inositol give cause to move to Phase 3...
Yet again, lithium has failed to live up to its promise in the treatment of amyotrophic lateral sclerosis...