Research Brief: Secretory Hormones—Example of Functional Amyloid?
Though it remains a prime pathological hallmark of Alzheimer disease, Aβ amyloid has yet to convincingly prove itself as the major toxic species driving AD...
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Though it remains a prime pathological hallmark of Alzheimer disease, Aβ amyloid has yet to convincingly prove itself as the major toxic species driving AD...
The simple act of opening an e-mail or saying “I love you” is out of reach for many people paralyzed by accident or disease, but 40 of them could get the chance to try out brain-computer interfaces...
The mutant protein that causes Huntington disease blocks axonal traffic by putting the molecular equivalent of the wheel-locking “boot” on motor proteins...
It’s enough to make a doctor’s head ache—antithrombotic drugs may protect people from stroke or heart attack, but the same medications may also increase risk of cerebral microbleeds...
Used largely as a last-ditch option for taming unruly motor symptoms in some PD patients, deep brain stimulation (DBS) might hold potential for treating dementia as well...
A new study strengthens the idea that Reelin, an extracellular matrix protein essential for brain development, works, at least in part, by binding APP...
Paris: Diabetes, Insulin, and Alzheimer Disease Ipsen Colloquium on Alzheimer’s Disease 2009
The mechanisms linking insulin to neurodegeneration were examined at the Fondation IPSEN 24th annual colloquium on Alzheimer’s Disease, held in Paris on 6 April 2009...
Amyloid-β (Aβ) peptide oligomers have come under intense scrutiny as the prime suspects in the synapse loss and neurotoxicity associated with Alzheimer disease...
Researchers report that from a tiny injected seed, tau pathology eventually spreads to anatomically connected areas of the mouse brain...
To determine if a medicine works, scientists need reliable patient data, but the right numbers are not always easy to come by...
Amyotrophic lateral sclerosis, already a rare condition affecting one to three people in 100,000, nonetheless garners most of the attention in the field of motor neuron disease...
Two of the promises of genetic association studies are better animal models for research and development of therapeutics...
Calculating the risk of impending AD based on levels of CSF Aβ42 has been tricky because the peptide forms insoluble aggregates that muddle estimates of its production rate in the CNS...
Interest in hitting nicotinic acetylcholine receptors for AD treatment is smoldering just below the surface...