In Mice, Huntingtin Defects Start in the Womb
The debilitating symptoms of Huntington disease typically manifest in people’s thirties and forties, but scientists have found that more subtle problems occur earlier...
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The debilitating symptoms of Huntington disease typically manifest in people’s thirties and forties, but scientists have found that more subtle problems occur earlier...
One hypothesis for the death of motor neurons in amyotrophic lateral sclerosis (ALS) is that the neurons become hyperexcited...
Two papers in today’s issue of Cell Stem Cell make one thing clear: the growth of new neurons relies on proper inhibitory GABA signaling...
Several posters beefed up the concept that signaling via calcineurin and NFATs may play a central role in neurodegenerative disease pathogenesis...
Functional neuroimaging studies show elevated activation in the brains of patients with mild cognitive impairment (MCI)...
While much attention has been focused on spinal cord processes in ALS, the innate immune system has been quietly going about its own business in the peripheral nervous system...
Boosting neurotransmitter signaling to compensate for sagging synapses and neuron loss in Alzheimer disease has met with skepticism...
If proteins could guest on TV game shows, then amyloid-β would make a good candidate for <em>What’s My Line?</em>...
The most recent study on the long-term cognitive effects of anesthesia and surgery suggests that elderly people going under the knife have little reason to worry...
The aberrant re-entry of post-mitotic neurons into the cell cycle is an early event in AD pathology, preceding amyloid deposition...
If papers on Aβ mechanism are an Alzforum reporter’s bread and butter, this week offers a triple feast...
Activated protein C delivers a one-two-three punch to disease in a mouse model of amyotrophic lateral sclerosis (ALS)...
At the second annual Clinical Trials on Alzheimer’s Disease meeting, prevention—how, when, with what interventions—dominated the discussions...
Did you know that if you had a spinal tap for a cerebrospinal fluid-based Alzheimer's diagnosis in Boston, Stockholm, London, or San Diego, the readout would likely be different in each place? And different again this year and next? That's a pro
Here, now, is a summary of the nuts and bolts of the QC program itself...