LRRK2 Pathway Offers Up New Targets in Parkinson’s
Mutations in the gene encoding LRRK2 (aka tyrosine kinase leucine-rich repeat kinase 2) are the most common cause of hereditary Parkinson disease...
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Mutations in the gene encoding LRRK2 (aka tyrosine kinase leucine-rich repeat kinase 2) are the most common cause of hereditary Parkinson disease...
Understanding how genetic variation contributes to human disease has become a major thrust of modern science...
Cutting calories may be good for the brain as well as the waistline...
When proteins fail to curl up in the right conformation, molecular chaperones sort them out, or the misfits are tagged for destruction...
When Nigel Leigh started scanning the brains of people with ALS in the early 1990s, colleagues said he was wasting his time...
The New York Times yesterday continued its coverage of the contentious question of whether repeated sports concussions predispose a fraction of players to brain damage...
Two new papers add to growing evidence linking diabetes and neurodegenerative disease...
Iron is an essential cofactor in many metabolic processes, but it can also be a dangerous parcel...
Last week’s PNAS online describes some new gross anatomical and electrophysiological changes that accompany Alzheimer disease (AD) and frontotemporal dementia (FTD)...
The idea of the default mode network quickly became a hot topic in cognitive neuroscience and for Alzheimer disease researchers...
Whether you’re a job seeker or a postmitotic cell, it’s not a good idea to burn your bridges...
Dogs who suffer from degenerative myelopathy carry a mutation in the gene for superoxide dismutase 1 (SOD1)...
The precise mechanism and significance of APP epsilon cleavage has been debated since it was discovered some 10 years ago...
Eight families with the rare neurodegenerative disorder Perry syndrome share mutations in the cellular transport protein dynactin...
Fragile X mutations are the most common cause of inherited mental retardation, and often cause autistic symptoms and epilepsy...