Coll(o)iding With Physical Chemistry: Amyloid Inhibitors Questioned
Blocking amyloid fibrillization with small molecules is a widely studied strategy for tackling Alzheimer disease and other amyloidoses...
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Blocking amyloid fibrillization with small molecules is a widely studied strategy for tackling Alzheimer disease and other amyloidoses...
Parkinson disease (PD) is a bit of an enigmatic mix...
To stop the destruction of neurons in Alzheimer disease requires an understanding of how the two protein perpetrators, amyloid-β and tau do their dirty work...
Transient episodes of neurological symptoms—muscle weakness, double vision, or other signs that last less than 24 hours—reveal underlying circulatory problems in the brain...
Is it futile to buck the trend that insulin resistance and dysfunctional insulin/insulin-like signaling contribute to neurodegeneration?...
A paper in the Journal of Clinical Investigation online supports the idea that ABCA1 can protect against amyloid buildup...
Can an FDA-approved arthritis drug double as a therapy for Alzheimer disease?...
It was 2 years ago that the ARF news desk noted a resurgence of interest in tau...
The hypothesis that more years of formal education protect the brain against the ravages of dementia may have just gotten a higher grade...
Part 1 of this story covered the growing evidence linking diabetes with Aβ pathology and cognition. But what about the other major hallmark of Alzheimer disease, neurofibrillary tangles?...
Next time you reach for yet another soda, consider this...
Using the roundworm <em>Caenorhabditis elegans</em> as a model, researchers have fished out several new genes that might guard against certain forms of Parkinson disease...
A new fly model of Huntington disease (HD) reveals a novel pathogenic mechanism for the polyglutamine-expanded huntingtin protein...
You can’t keep a good mitochondrion down. Or maybe you can...
Lithium is an old and much used psychiatric drug, whose mechanism of action remains murky...