Technology Brief: Advances in Nanoscopy Deliver Cellular Close-Ups
Pushing the limits of light and electron microscopy, two new studies promise to open up ever more detailed nano-vistas into cells and tissues...
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Pushing the limits of light and electron microscopy, two new studies promise to open up ever more detailed nano-vistas into cells and tissues...
Proposed causes of Alzheimer disease may abound in the scientific literature, but many focus on a common endpoint: sputtering synapses that spell death for neurons...
Many researchers studying neurodegenerative disease focus their studies on the affected organs of the nervous system. But in doing so, they may be ignoring a more accessible place...
Imaging the brain through ultra-thin bone windows into the brains of live mice, scientists see in vivo that amyloid plaques form and reach their full size over a period of weeks...
Researchers have identified age-dependent learning problems that seem to stem from defects in synaptic function...
For a motor neuron to maintain the unwieldy meter-long axons that innervate the lower limbs requires all the cell’s parts to work together perfectly...
Building a healthy axon, like erecting a skyscraper, takes a variety of workers and materials...
Hopes of bringing M1’s therapeutic potential to the clinic have resurged with recent data hinting at better success by targeting allosteric sites...
How does a nice (that is, soluble and relatively unstructured) protein like tau end up rigidly locked into paired helical filaments and neurofibrillary tangles?...
As is true with getting into college or receiving a job offer, it’s not just pedigree but also life experiences that may determine whether a person will develop Alzheimer disease...
The idea that natural variants of a single gene could substantially influence brain structure might blow your mind...
The energy needs of neurons are prodigious—the brain makes up just a small percentage of the body, yet burns roughly 25 percent of its calories...
Chances are, when asked to list possible causes for Parkinson and Alzheimer diseases, many scientists would not think to include flu virus...
Consider browsing this week’s JAMA over a glass of wine, because it may take time to digest and appreciate their nuanced conclusions...
Do we use it or lose it, or use it and lose it? If synaptic activity spurs Aβ production, why do education, environmental stimulation, and socialization all protect against AD?