Drug Brief—Adverse Events Prompt Dose Drop in Elan Trial
It appears that Dublin-based Elan's small molecule drug candidate ELND005 has run into some trouble...
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It appears that Dublin-based Elan's small molecule drug candidate ELND005 has run into some trouble...
It is not just material goods that are best when they come in small packages, but amyloid-β (Aβ) as well...
Swapping a single cytosine for a thymine in a gene involved in protein secretion more than doubles a person’s risk of amyotrophic lateral sclerosis (ALS)...
It may be time to add “slowing amyotrophic lateral sclerosis” to the growing list of tasks accomplished by microRNAs...
Researchers report that a mere doubling of brain LDLR levels in AD transgenic mice is enough to substantially curb deposition and hasten clearance of Aβ...
SORLA (aka SORL1) controls the trafficking and processing of the amyloid precursor protein (APP), and thus serves as a key regulator of amyloid-β...
Chicago: Axonal Transport Not So Fast in Neurodegenerative Disease Chicago: Tau and α-Synuclein Oligomers Follow Aβ Footsteps Chicago: Nicotinic AChRs: α4β2 Iffy for AD, More Promise With α7? Chicago: Move Over, Agonists; Make Way for Modulators Chicago:
Pyroglutamate Aβ has been making a return to center stage in AD research after languishing in relative obscurity for a decade following its initial discovery...
Exactly which form the amino end of Aβ takes in the brains of people with AD is a question that increasingly crops up in talks about immunotherapy and even other dementias...
Could foresight be 2020 for Alzheimer disease? Zaven Khachaturian has proposed a national strategic plan of preventing the disease within 11 years...
Now, with the use of in vivo imaging, two groups have caught dendrites in the act of rewiring cortical circuits in live mice experiencing motor or sensory learning...
The debilitating symptoms of Huntington disease typically manifest in people’s thirties and forties, but scientists have found that more subtle problems occur earlier...
One hypothesis for the death of motor neurons in amyotrophic lateral sclerosis (ALS) is that the neurons become hyperexcited...
Two papers in today’s issue of Cell Stem Cell make one thing clear: the growth of new neurons relies on proper inhibitory GABA signaling...
Several posters beefed up the concept that signaling via calcineurin and NFATs may play a central role in neurodegenerative disease pathogenesis...