New Drugs—FDA Approved, But Where’s the Data
No one would want to make a major investment without carefully weighing the pros and cons...
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No one would want to make a major investment without carefully weighing the pros and cons...
Mouse models and biochemical studies have implicated protein phosphatase 2A (PP2A) in curbing tau hyperphosphorylation in Alzheimer and other diseases...
Four new mouse studies sketch how molecular alterations involving neuregulin-1 (Nrg1) might lead to neurological and behavioral deficits in schizophrenia...
Tom Fagan Interviews Deborah Blacker
The tiny fruit fly <em>Drosophila</em> has served researchers well to unravel the function of genes linked to neurodegeneration in Parkinson disease...
If pyroglutamate Aβ sounds like some sort of Alzheimer disease incendiary device, then could inhibitors of the enzyme that sparks pyroglutamate formation extinguish the disease?...
Recent evidence points toward glia as cells gone terribly wrong in promoting the pathology that drives amyotrophic lateral sclerosis...
As drug makers try to rescue dying neurons, others hold out hope that supplying fresh ones may be a better way to combat Alzheimer and other neurodegenerative diseases...
Growing postmortem evidence suggests that repeated early-life concussion sets off a pathological cascade in the brain...
Robert Katzman was a pioneer in bringing Alzheimer disease out of obscurity and into the forefront of medical, scientific, and social agenda of this country...
Robert Katzman, a leader in the field of Alzheimer’s research, died at his home in La Jolla, California, last week...
Showing that an experimental Alzheimer’s therapy delivers meaningful cognitive change is hard enough...
Flagging mitochondria, the powerhouses of the cell, have been linked to general aging and also to a variety of neurodegenerative diseases...
The presence of small oligomeric protein assemblies with neurotoxic properties has become a common thread in several neurodegenerative diseases...
Experimental evidence and plain common sense tell us that neurons lose activity in Alzheimer disease...