Of Axons and Root Hairs: Plants in the Neurodegeneration Lab?
For a motor neuron to maintain the unwieldy meter-long axons that innervate the lower limbs requires all the cell’s parts to work together perfectly...
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For a motor neuron to maintain the unwieldy meter-long axons that innervate the lower limbs requires all the cell’s parts to work together perfectly...
Building a healthy axon, like erecting a skyscraper, takes a variety of workers and materials...
Hopes of bringing M1’s therapeutic potential to the clinic have resurged with recent data hinting at better success by targeting allosteric sites...
How does a nice (that is, soluble and relatively unstructured) protein like tau end up rigidly locked into paired helical filaments and neurofibrillary tangles?...
As is true with getting into college or receiving a job offer, it’s not just pedigree but also life experiences that may determine whether a person will develop Alzheimer disease...
The idea that natural variants of a single gene could substantially influence brain structure might blow your mind...
The energy needs of neurons are prodigious—the brain makes up just a small percentage of the body, yet burns roughly 25 percent of its calories...
Chances are, when asked to list possible causes for Parkinson and Alzheimer diseases, many scientists would not think to include flu virus...
Consider browsing this week’s JAMA over a glass of wine, because it may take time to digest and appreciate their nuanced conclusions...
Do we use it or lose it, or use it and lose it? If synaptic activity spurs Aβ production, why do education, environmental stimulation, and socialization all protect against AD?
Genomewide association studies reported by two groups converged on three hits for sporadic Alzheimer disease (AD), ApoJ, CR1, and PICALM...
Aggregates of α-synuclein are the principal component of Lewy bodies, neuronal inclusions found in Parkinson and other neurodegenerative diseases...
In the case of axonal transport, it may not be about who wins the race, but what’s carried to the finish line...
Synchrony and uniformity tend to characterize line dancers, but they may elude neurons when LINE-1 (long interspersed element 1) retrotransposons take the stage...
The theme “don’t go whole hog” might come to mind for those who check out two recent papers suggesting potential therapeutic strategies for Alzheimer disease...