In children as young as 9 who carry a presenilin 1 mutation, researchers detect subtle functional and structural brain changes.
By recording from individual human brain cells, researchers find that single neurons can instantly encode associations, showing how rapidly they form memories.
A Phase 2b trial finds that the monoamine oxidase B inhibitor sembragiline missed its primary endpoint.
The scale of cortical folding in mammals—from rodents to humans—is dictated by a simple relationship between surface area and thickness.
The Center for Open Science published eight guidelines for journals to boost transparency and reproducibility in research. Will journals implement them?
One, NF-κB, was thought to be protective but seems to have a detrimental role in ALS.
Live imaging in mice finds that smooth muscle cells on arterioles exclusively control cerebral blood flow.
Worm study suggests that tipping the balance between progranulin and its granulin fragments might promote frontotemporal dementia.
Better known for lowering cholesterol, statins appear to spur the production of neurotrophins in the brain.
In mice harboring both pathogenic α-synuclein and Aβ, the former puts the brakes on plaque formation by the latter. The model could offer insight into what happens in people with mixed pathology.
Live imaging combined with mathematical modeling suggests that dendritic spines in the hippocampus disappear on the same time schedule as short-term memories fade.
The mice, which lack the ALS- and FTD-linked gene in neurons, indicate that C9ORF72 loss of function alone cannot cause neurodegeneration.
The enzyme complex directly cleaves a protein crucial for survival of B cells, debuting a new type of substrate for the protease.
One author falsified figures, prompting the lab to request a retraction.
The model provides the first functional evidence of how the ALS gene UNC13A modifies disease risk.