Andropause Accelerates Aβ Deposition in Mice
Testosterone levels decline as men age, and the urge to treat this natural process with hormone replacement has sparked controversy...
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Testosterone levels decline as men age, and the urge to treat this natural process with hormone replacement has sparked controversy...
A new study in yesterday’s New England Journal of Medicine shows that PET imaging using the amyloid-binding agent FDDNP can...
The prospects of using cerebrospinal fluid biomarkers to diagnose Alzheimer disease may have just gotten a bit brighter...
Feeding an extract of Ginkgo biloba leaves reduced the levels of soluble Aβ oligomers and the pathological effects of amyloid-β (Aβ) expression in...
Researchers thought they had dealt their newborn mice a death blow by deleting the Numb and Numb-like genes in the neural progenitor cells of the subventricular zone...
One of the earliest signs of amyloid-β (Aβ) toxicity is synaptic loss, and recent work from a number of labs has shown that...
The human ApoE4 isoform is the biggest single risk factor for sporadic Alzheimer disease (AD)...
Mutations in presenilin associated with familial Alzheimer disease perturb calcium signaling in cells. In particular, some mutations suppress...
On Monday, federal prosecutors brought criminal conflict of interest charges against...
Dementia strikes in many forms besides Alzheimer disease, and two recent reports take a look at the biochemical basis for dementias in other settings...
Neurons cannot afford to be spineless. Not only are those dendritic protrusions essential for transmitting incoming signals from other neurons, but...
The NAD synthesizing protein nicotinamide mononucleotide adenylyltransferase (Nmnat) got the attention of neuroscience researchers as...
Two new papers reveal how environmental influences can directly affect the activity of the APP-processing enzymes β-secretase (BACE1) and γ-secretase...
When it comes to pathological variations in the human genome, single nucleotide polymorphisms have taken their fair share of the heat...
Many researchers are acquainted with Arc/Arg3.1 as a marker of neuronal activity in the brain. The gene is induced by...