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Lipid Membranes—Order from Chaos

In yesterday's Nature, Tobias Baumgart and colleagues shine some light on the fluid dynamics of biomembranes using two-photon microscopy to visualize lipids that separate into coexisting liquid phases, or domains, in giant unilamellar vesicles...

Soluble Aβ: Getting a Grip on Its Fate

In Alzheimer’s patients, a portion of soluble amyloid-β peptides (sAβ) never makes it out of the brain as in normal subjects, ending up instead in amyloid fibrils or plaques. A trio of recent papers explores factors that determine the fate of these peptides...

ALS—Is It the Neurons or the Glia?

One well-characterized cause of amyotrophic lateral sclerosis (ALS) is mutation of the copper-zinc isoform of superoxide dismutase (SOD), causing progressive degeneration of motor neurons. But must these mutations occur in neurons to be detrimental? A report in today’s Science suggests...

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