Oligomers block outer membrane translocases, starving the organelles of essential respiratory chain components.
In a large affected family, mutation of a transmembrane protein implicates defective cellular recycling in the disease.
Presenilin 2 resides almost exclusively in late endosomes, multivesicular bodies, and lysosomes, where it generates a pool of aggregation-prone Aβ. Some PS-1 mutations phenocopy this intraneuronal distribution.
Levels of neurofilament light in blood and spinal fluid of mice reflected brain pathology and changed with treatment.
A bill approved by the U.S. Senate Appropriations Committee would increase funding for Alzheimer’s and related dementias by 40 percent.
The misfolded miscreants interact with their normal brethren on the neuronal surface to trigger the damage, but how and whether this collapse relates to prion propagation remains a mystery.
Scientists find two spots on the genome that may influence how long a person will live with amyotrophic lateral sclerosis.
In a glaucoma model, blocking tau accumulation in cell bodies and dendrites of retinal neurons kept them alive.
Anti-platelet therapy might treat vascular dementia, researchers suggest.
Mice lacking the receptor have more diffuse plaques, more dystrophic axons, and more neurodegeneration. The TREM2-microglia hail from inside the brain.
In mammalian cells, worms, and mice, Aβ snags yeast and bacteria in a fibril mesh, preventing their assault on host cells.
Age-related attrition of the male chromosome in blood cells raises the risk of Alzheimer’s disease. Researchers suspect immune cells are compromised.
A compound that binds mGluR5, a potential Aβ receptor, lowered amyloid pathology and improved cognition in two mouse models of Alzheimer’s disease.
A small trial suggests the drug liraglutide bolsters glucose metabolism in the brains of people with Alzheimer’s, but whether this modifies their disease remains unknown.
Researchers find high levels of certain pesticides in the blood of people with ALS, while in neuronal cultures some of them caused gene expression changes reminiscent of Alzheimer’s.
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