More-active animals maintained healthier neurovascular systems if they carried the ApoE gene.
Researchers at SfN 2015 outlined perinatal treatments that rescued cognition in mouse models of the disease.
The RNA-binding protein hnRNP A3 can help rid a cell of the repeat RNAs, but the RNAs interfere with its nuclear localization.
Research presented at SfN strengthens the case that microglia gorge on synapses in some neurodegenerative and neurodevelopmental disorders.
Researchers think montelukast could hold promise for people with neurodegenerative disease.
C9ORF72 Mice Point to Gain of Toxic Function in ALS, FTD Does C9ORF72 Repeat RNA Promote Protein Phase Transitions? RNA Regulator Locked Out of Nucleus by C9ORF72 Repeats Listen Up, Gene Silencing Strikes a Chord at RNA Meeting Stressed Out: RNA-binding ...
The ALS-linked RNA may convert free-floating proteins to liquid phase droplets.
Phenotypes vary depending on the partial or full-length nature of the C9ORF72 transgene.
Basic science inspires conference goers in Chicago.
The ALS- and FTD-linked protein condenses into liquid organelles but also tends to form hydrogels, some of which are permanent and toxic.
Snapshots from the Society for Neuroscience Annual Meeting Microglia Control Synapse Number in Multiple Disease States Might Normalizing Brain Development Help in Down’s Syndrome? Potential Parkinson’s Treatments Target α-Synuclein, Cell Replacement ...
Recent studies exemplify the burgeoning array of stem cell strategies to treat neurodegeneration, ranging from sending in supportive cells to switching out neurons.
The blood-brain barrier barred passage of antibodies in multiple mouse models of neurodegenerative disease, suggesting it holds up well in the face of disease.
Grid cells in the entorhinal cortex help with spatial navigation, and the cells’ function falters in young people at risk for AD.
Moving toward a common standard for fluid-based Alzheimer’s diagnosis in routine clinical care, an intergovernmental metrology agency has certified a way of quantifying Aβ42.
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