Meet ADCS-PACC, C3: Composites that measure subtle changes in cognition appear reliable, clearing the way for their use in clinical trials of people with presymptomatic AD.
New strategies may help find and retain participants for Alzheimer’s trials.
New research strengthens the idea that microglia do far more than scour the brain for emergencies.
In neurodegenerative disease, tau is in the dendrites, and scientists are beginning to flesh out ways to block what it does there.
Early dysfunction in Alzheimer’s may start in the lateral entorhinal cortex and spread from there to connected cortical brain regions.
Researchers have co-opted a molecular transport system to shuttle Aβ antibodies across the mouse blood-brain barrier. They predict the shuttle could smuggle a variety of drugs into the brain.
A transcription factor thought to mark stressed-out motor neurons activates genes that help them survive. It maintains muscle mass, but not strength.
A small study suggests that exposure to the pesticide DDT heightens the risk of developing Alzheimer’s disease.
Researchers have sliced and digitally reassembled a famous brain in neuroscience to view its detailed three-dimensional architecture.
Government, industry, and advocacy together will provide nearly $130 million for the identification of surrogate markers and targets.
Researchers have detected elevated endogenous tau in the cerebrospinal fluid of Aβ mouse models.
Researchers report that they can visualize the "glymphatic pathway" in rat brains by using contrast-enhanced magnetic resonance imaging...
As attention shifts toward free-floating Aβ oligomers as the prime molecular culprits in AD, there is still plenty of confusion over the role of fibrillar amyloid...
Skin cancer, a common and typically curable malignancy, may carry a fringe benefit—protection from Alzheimer’s disease...
Microglia have taken center stage in Alzheimer’s disease (AD) research recently...