The largest meta-analysis done to date confirms dramatic variability in age at onset of autosomal-dominant Alzheimer's disease overall, but finds mutation type and parental age at onset to be strong predictive modulators.
Engaging in cognitive activities throughout life staves off decline. It also delays Aβ accumulation, two studies report.
A novel mutation frays mitochondrial DNA and impedes ATP synthesis in people with an ALS-FTD-like syndrome.
Head injury increases one’s chances of future dementia by 60 percent, according to a study in veterans.
Scientists report that astrocytes help neurons destroy their unwanted mitochondria.
A new interface allows researchers to mix and match data from genome-wide association studies in search of genes involved in sporadic amyotrophic lateral sclerosis.
Levodopa may have a slight edge over newer treatments for Parkinson’s disease.
Passive immunotherapy shows moderate success in a mouse model of sporadic Parkinson’s disease.
Researchers argue for a public-private superfund to advance many Alzheimer’s therapeutics projects in parallel.
Scientists advance a new explanation for how Aβ dampens synaptic plasticity.
Alpha-secretase does not necessarily pick up the slack when β-secretase cleavage of amyloid precursor protein wanes, a study in primates finds. It suggests APP can be processed in other ways.
Belying some earlier reports, a new study finds that grafted dopamine cells continue to innervate neural networks years after transplantation.
An amplification-based test picks up minute amounts of prion protein in the blood of asymptomatic carriers, but researchers wonder whether regulators will want to screen the population.
Patient-derived macrophages are the latest model of Gaucher’s disease, a lysosomal storage disorder. The cells may help researchers better understand disease phenotypes and test candidate therapies.
Does amyotrophic lateral sclerosis start at the interface between mitochondria and the endoplasmic reticulum?