Researchers debut a statistical model that uses MRI, CSF, and demographic data to compute a cognitively impaired person’s risk for progressing to dementia.
Using a new algorithm that measures mRNA decay rates more accurately than before, scientists claim that two RNA-binding proteins and four miRNAs determine the stability of mRNAs in the brain. Loss of RBFOX1 may destabilize synaptic protein mRNAs in Alzheimer’s disease.
A single-nucleotide polymorphism near the TMEM106b locus boosts expression of the gene, which is linked to frontotemporal dementia.
In a massive project analyzing gene expression patterns among 44 human tissues from 449 people, researchers correlated genetic variation with region-specific transcriptomes.
Seizures in AD mice lead to cognitive changes via epigenetic suppression of calbindin-D28k.
Relatives of patients who have ALS are more likely to live with neuropsychiatric diseases such as schizophrenia, obsessive-compulsive disorder, and alcoholism.
Intestinal flora helps fight infection, inflammation, and cancer. What could this mean for neurodegeneration?
TREM2 accelerates neurodegeneration in one tauopathy model, but reduces tau pathology in another. Whether the microglial protein is good or bad may depend on stage of disease.
New CRISPR screen flags dozens of genes that suppress toxicity of the Parkinson’s protein. Tweaking multiple genes strengthened the protection.
Using modified MRI protocols, researchers were able to visualize these vessels in the dura mater of living people. The discovery challenges conventional wisdom.
Researchers claim this failed drug allows Aβ to accumulate inside cells, while small peptides cleaved from the C-terminal end of APP become trapped in membranes.
Human endothelial cells, smooth muscle cells, and astrocytes combine to form a vessel that ferries away Aβ, particularly Aβ42.
PET scans show a tangle patch in the entorhinal cortex when people report subjective cognitive concerns.
Young tau knockout mice maintain healthy brain tissue after ischemia, while older knockouts lose this stroke protection due to brain iron buildup.
Three developers of cryo-electron microscopy—the technique researchers recently used to unveil atomic structures of γ-secretase, Aβ, and tau fibrils—won this year’s Nobel Prize in chemistry.