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Summary of Technology Discussions: Bar Harbor

Tim Clark began by laying out recommendations about the information infrastructure required if many groups want to be able to do collective experimentation, to share data, and to exploit automated pattern recognition in that shared data.

Making the Search for Snips More Parallel

In the search for those mostly still-elusive SNPs that are widely thought to predispose to complex, multigenic diseases such as schizophrenia and heart disease, one technical hurdle that slows down the search is the sheer amount of sequencing required...

Evidence on Iron Accumulates

It has been clear for a number of years that iron accumulates in areas such as the hippocampus in Alzheimer's disease and the substantia nigra in Parkinson's disease. Just what this means is...

Huntingtin Regulates BDNF

The gene mutation that causes Huntington's disease has been known for many years, yet the function of the encoded protein, huntingtin, and the pathogenic mechanism of the mutant protein, have remained frustratingly elusive...

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