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Caloric Restriction Increases Metabolic Rate

It has been known for sometime that reduced intake of calories increases the lifespan of many species, including mammals, but just exactly how this works is unclear. Now work from Leonard Guarente’s lab at MIT suggests that <em>increased</em> respiration is what extends lifespan—at least in yeast....

New Role for NO in Neuronal Apoptosis

In today’s Science, researchers from the Burnham Institute, La Jolla, California, report a new pathway that can cause neuronal apoptosis, or programmed cell death—the covalent modification of extracellular matrix metalloproteinases (MMPs)....

Fat and Calories Mean Higher AD Risk

When it comes to food and the quality of life there is a growing wealth of knowledge that suggests “less is more.” This mantra is supported by a new study associating high caloric intake with increased risk for Alzheimer’s disease (AD)....

Turning Stem Cells into Motor Neurons

In today’s issue of the journal Cell, researchers at Columbia University, New York, report they have figured out a way to coax ES cells into becoming motor neurons, opening up some exciting new possibilities for treating a variety of diseases...

Stockholm: Pictures at an Exhibition

Keith Crutcher reports on the World Alzheimer Congress in Stockholm. "From the relatively crude days of CT scans to the truly impressive detail now being offered by functional MRI, this revolution in imaging technology is making it possible to study the course of AD in ways previously unimaginable...."

Stockholm: Core Resistance

Keith Crucher reports from the World Alzheimer Congress: In the symposium on amyloid-lowering strategies, Dennis Dickson presented a unique and clever approach to addressing the likelihood that macrophage-mediated clearance of amyloid will be an effective strategy in humans....

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