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APP Enhances Mouse Memory

Secreted forms of amyloid precursor protein (APP) may play an important role in the formation and consolidation of memory, according to a study published in today's proceedings of the National Academy of Science...

Nature Online

The British science journal Nature announced that it is becoming a "full-fledged" electronic journal beginning with this week's issue (at <a href="http://www.nature.com">http://www.nature.com</a>)...

Casting Doubt on Role of Oxidative Damage in ALS

Mutations in the enzyme for superoxide dismutase (SOD1) have been linked to 15 tp 20 percent of cases of amyotrophic lateral sclerosis (ALS), leading to a theory that the disease results when the defective enzyme allows super oxide radicals to build up...

How NF-kB Derails Apoptosis

A study published in tomorrow's Science provides new details of how the transcription factor NF-kB protects cells from apoptosis. C.-Y. Wang and colleagues report they have identified four genes that are targets of NF-kB activity...

Mitochondria Key to Glutamate Toxicity

Glutamate is a neurotransmitter that is toxic when too much of it is released by excessive neuronal activity or by brain injury. Some researchers have also proposed that glutamate toxicity drives the neurodegeneration...

Dopamine Transporter Imaging

A novel brain-imaging agent that binds selectively to dopamine transporter molecules promises to open up a window on the functioning of the brain's dopamine system. Dopamine is one of the brain's major neurotransmitters...

Potential NGF Drug-Delivery System

Puny polymer pellets show promise as a vehicle for delivering nerve-growth factor (NGF) to the basal forebrain, where the substance could rescue or even regenerate neurons damaged by Alzheimer's disease...

Epilepsy Drugs Effective for Agitation in AD

For many families caring for an Alzheimer's patient, it is not the memory impairment per se that drives them to place their loved one in a nursing home, so much as the agitation, aggression and even violence that demented patients frequently exhibit...

Membrane Rafts Revealed

It has been theorized that cell membranes contain stable regions consisting of glycolipids and cholesterol. They are called detergent-insoluble glycolipid-enriched membrane domains (DIGs)...

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