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Copper to the Rescue?

After years as a potential but peripheral suspect in the pathogenesis of Alzheimer's disease, copper (Cu) is lobbying for a new designation—potential therapy! Two studies in the November 17 PNAS Early Edition suggest that copper can...

RUNX1 an Autoimmunity Master Switch?

In this month's Nature Genetics, two papers reveal that single nucleotide polymorphisms (SNPs) in the binding site for a single protein called Runt-related transcription factor 1 (RUNX1) can lead to either psoriasis or rheumatoid arthritis...

Neuroimmunology Potluck: NSAIDs, Genes, and Inflammation

The table of evidence regarding inflammatory and even autoimmune processes in Alzheimer's continues to accumulate in a piecemeal fashion, awaiting experimental breakthroughs to give it direction and a greater following. But accumulate it does, and in this article we summarize some of the recent appetizers...

Mapping Interactions in the Drosophila Proteome

Researchers have identified over 20,000 different interactions among over 7,000 proteins that are coded in the genome of the fruit fly <em>Drosophila melanogaster</em>, allowing them to create extensive and intricate protein-protein contact maps...

New Tau Kinase Makes Its MARK

Gerard Drewes and colleagues at Cellzome, Heidelberg, Germany, and the University of Kansas at Lawrence, report in the November 1 Journal of Biological Chemistry online the characterization of a tau kinase called MARK 4...

Pushing Longevity to the Max

In today's Science, Cynthia Kenyon and colleagues at the University of California, San Francisco, report that they have generated transgenic nematodes, <em>Caenorhabditis elegans</em>, that live six times longer than normal, the equivalent of about a 500-year lifespan in humans...

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